spectrophotometry, high-performance liquid chromatography (HPLC) and liquid chromatography–mass spectrometry
نویسندگان
چکیده
Photonic crystal (PC) microcavities formed by 2D air holes on silicon-on-insulator substrates were utilized as biosensors to detect antibiotics with high specificity. The antibiotic, gentamicin, with molecular weight of only 478 g/mol, was successfully detected via its binding to corresponding antibody pre-immobilized on the sensor surface. Detection range (in concentration) was extended by combining different types of PC biosensors on a single silicon chip, covering from 0.1nM to 1μM. Specificity of detection was also verified on the studied antibiotic.
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